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Oncology

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The Epidemiological and Metabolic History of Dietary Sugars: A Two-Century Analysis of Chronic Disease and Oncology The macronutrient composition of the human diet has undergone a profound transformation over the past two centuries, characterized most distinctly by the exponential increase in the consumption of refined sugars.

The scientific endeavor to understand the relationship between sugar consumption and human pathology has been highly contentious, oscillating between early clinical dietary restrictions, mid-century epidemiological controversies, and modern molecular oncology.

It traces the evolution of medical thought from early hypotheses characterizing diabetes and cancer as diseases of civilization to contemporary biochemical models elucidating the direct and indirect pathways of carcinogenesis, lipogenesis, and metabolic dysfunction.

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